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Adderall is a stimulant medication used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Adderall refers to central nervous system (CNS) stimulants that change the amount of certain chemicals in the brain to reduce impulsivity and hyperactivity.

Although the main use of this drug is to treat attention deficit disorder, some people use it for entertainment. Others - to improve athletic performance due to the fact that it provides increased energy and concentration.

What is Adderall used for?

Treatment for ADHD. Adderall is a treatment option when psychotherapy and behavior management methods do not help.

Treatment of narcolepsy. Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness. People feel excessively tired or sleepy during the day and may fall asleep at the wrong time.


  • Children under 6 years old.
  • Severe depression or suicidal thoughts, bipolar disorder, mania, schizophrenia, psychosis, personality disorder, or anorexia nervosa.
  • Cardiovascular disease, including structural heart disease, irregular heartbeat, heart failure, hypertension, angina, or a recent heart attack.
  • Blood vessel disorders in the brain, such as an aneurysm, vasculitis, or stroke.
  • Hyperactivity of the thyroid gland.
  • Tumor of the adrenal glands (pheochromocytoma).
  • Pregnancy and lactation.

How does it work?

Adderall regulates the functioning of neurons in the prefrontal cortex - the area of the brain involved in attention, decision making and impulse control - with few effects outside of this area.

Adderall acts as a catecholamine reuptake inhibitor, primarily dopamine and norepinephrine (norepinephrine). This reuptake inhibition promotes an increase in the extracellular concentrations of dopamine and norepinephrine, thereby significantly enhancing neurophysiological arousal.

When taken orally, Adderall blocks various transporters, resulting in a significant increase in dopamine and norepinephrine levels. Increased dopamine levels are associated with increased arousal and activity in the nervous system. An increase in dopamine improves learning ability, memory, and overall cognitive functioning. In some cases, this drug also improves mood and is sometimes used as an off-target strategy to increase the strength of antidepressants.

ADHD and other similar conditions are associated with a lack of efficiency of the functions of dopamine and norepinephrine in the brain. These functions are responsible for planning, behavior suppression, problem solving, reasoning, and so on.

Positive Effects

When taking Adderall, a number of "beneficial effects" appear: improved cognitive functions, reduced hunger, increased energy, increased metabolism, increased mood and increased sociability.

Although the beneficial effects of Adderall are attractive, they are often temporary and not sustainable for a long time. Most people using the drug experience rapid onset of tolerance and require frequent dose titration to maintain therapeutic efficacy.

Treatment for ADHD

It is believed that ADHD is associated with deficiencies in several neurotransmitter systems in the brain, Adderall corrects this deficiency by increasing the activity of neurotransmitters in these systems. Children with ADHD who use stimulant medications such as methylphenidate generally have better relationships with peers and family members, have longer attention spans, and perform better in schools.

Narcolepsy treatment

Narcolepsy is a chronic sleep disorder associated with a sudden need for sleep and overwhelming daytime sleepiness. Adderall is effective in increasing wakefulness and alertness.

Improving academic performance

Students sometimes use Adderall to improve their mental abilities. A systematic review of high-quality clinical trials showed that therapeutic doses of the drug lead to a small but clear improvement in cognitive function.